アートとサイエンス

眼胚が形成体として働くことで表皮から水晶体を誘導する際の分子機構

2019/01/13
 
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眼の発生

 Cvekl et al., 2014 Development Fig.3

レンズがあれほど透明な理由

Terminal differentiation of lens fiber cells occurs by loss of organelles and degradation of DNA. https://www.sciencedirect.com/sdfe/pdf/download/eid/1-s2.0-S0301468111613923/first-page-pdf

 

レビュー論文

  1. Aleš Cvekl, Ruth Ashery-Padan. The cellular and molecular mechanisms of vertebrate lens development. Development 2014 141: 4432-4447; doi: 10.1242/dev.107953
  2. F. J. Lovicu,J. W. McAvoy, and R. U. de Iongh. Understanding the role of growth factors in embryonic development: insights from the lens. Philos Trans R Soc Lond B Biol Sci. 2011 Apr 27; 366(1568): 1204–1218. doi: 10.1098/rstb.2010.0339
  3. Lena Gunhaga. The lens: a classical model of embryonic induction providing new insights into cell determination in early development. Philos Trans R Soc Lond B Biol Sci. 2011 Apr 27; 366(1568): 1193–1203. doi: 10.1098/rstb.2010.0175
  4. F.J.Lovicu, J.W.McAvoy. Growth factor regulation of lens development. Developmental Biology
    Volume 280, Issue 1, 1 April 2005, Pages 1-14 https://doi.org/10.1016/j.ydbio.2005.01.020
  5. Hajime Ogino and  Kunio Yasuda. Sequential activation of transcription factors in lens induction. First published: 25 December 2001 Development, Growth & Differentiation https://doi.org/10.1046/j.1440-169x.2000.00532.x

 

原著論文

  1. Toshiaki Mochizuki, Yutaka Kojima, Yuko Nishiwaki, Tetsuya Harakuni, Ichiro Masai. Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish. Development 2018 145: dev170282 doi: 10.1242/dev.170282 Published 15 October 2018
  2. Thuzar Thein, Jimmy de Melo, Cristina Zibetti, Brian S. Clark, Felicia Juarez, Seth Blackshaw. Control of lens development by Lhx2-regulated neuroretinal FGFs. Development 2016 143: 3994-4002; doi: 10.1242/dev.137760
  3. Dylan S. Audette, Deepti Anand, Tammy So, Troy B. Rubenstein, Salil A. Lachke, Frank J. Lovicu, Melinda K. Duncan. Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression Development 2016 143: 318-328; doi: 10.1242/dev.127860
  4. Faber et al., Fgf receptor signaling plays a role in lens induction. Development 128, 4425-4438 (2001) 4425 PDF
  5. Yasuhide Furuta and Brigid L.M. Hogan. BMP4 is essential for lens induction in the mouse embryo. Genes & Dev. 1998. 12: 3764-3775 doi:10.1101/gad.12.23.3764
  6. Steven Bassnett, Danijela Mataic. Chromatin Degradation in Differentiating Fiber Cells of the Eye Lens. Journal of Cell Biology 7 April 1997; 137 (1): 37 DOI: 10.1083/jcb.137.1.37 | Published April 7, 1997
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